FOXO4-DRI

A designed senolytic peptide that kills senescent cells in mice and cell culture. It has never been tested in a human trial.

Also known as: FOXO4-D-Retro-Inverso, FOXO4-p53 interfering peptide
Area: Longevity
Status: Experimental; never tested in people and not approved anywhere

Articles on FOXO4-DRI

LongevityPreclinical

FOXO4-DRI: a clever senolytic that has never been tested in people

FOXO4-DRI clears senescent cells in mice and in dishes of human cells. No human trial has been registered or published, so its effects and safety in people are unknown.

HPR Editorial · 5 Sept 2026 · 7 min read