RecoveryHuman study
BPC-157: what the evidence in people actually shows
A big rat literature, three tiny uncontrolled human reports and one long-silent colitis trial. Here is exactly what has been tested in people.
Human Peptide Research: plain-English breakdowns of the human research on peptides
Latest
Basics & safetyHuman study
Who should not use peptides: the screening list
Basics & safetyMeta-analysis
Research use only: what the label means in the UK and US
Free live webinar · Thursday 1 October · 7pm UK time
Join the next webinar: Introduction to Peptides
with Mitch O’Callaghan, ISSCA Peptide Therapist · Founder, Proper Protocols
- What peptides actually are, and how they differ from hormones and supplements
- How to tell a human trial from a mouse study when you read the claims online
- Who should not use peptides, and what proper screening looks like
- Live Q&A: bring your questions
HPRProper Protocols
Your hostMitch O’CallaghanISSCA Peptide Therapist · Founder, Proper ProtocolsSave my free placeFree · live online · with Q&ANew human studies
All studiesBasics & safetyHuman study
Who should not use peptides: the screening list
Active cancer, pregnancy and a known allergy rule peptides out. Several other conditions need a specialist first. Here is the list, and where each item comes from.
Basics & safetyMeta-analysis
Research use only: what the label means in the UK and US
“Research use only” is a seller’s statement, not a legal category. In both countries regulators look at how a product is sold and used, and a disclaimer doesn’t settle that.
MetabolicHuman RCT
Retatrutide: what the trials show so far, and what is still a press release
Peer-reviewed trials show 24% weight loss at 48 weeks and large falls in liver fat; the headline 28% phase 3 figure is still company-reported.
Guides and safety
All researchBasics & safetyHuman study
Who should not use peptides: the screening list
Active cancer, pregnancy and a known allergy rule peptides out. Several other conditions need a specialist first. Here is the list, and where each item comes from.
MetabolicHuman RCT
Retatrutide: what the trials show so far, and what is still a press release
Peer-reviewed trials show 24% weight loss at 48 weeks and large falls in liver fat; the headline 28% phase 3 figure is still company-reported.
HormonesHuman study
Follistatin-344: the human trials used gene therapy, not an injected peptide
Every human study of follistatin-344 delivered the gene by viral vector into muscle, in a handful of patients. The protein sold in vials has no human data behind it.
First-hand experiences
Read all reportsFirst-hand reportSelf-reported
Blood markers of a man 20 years younger. Sleep fixed, energy fixed, every single marker optimal. I'm in the best health of my life at over 50 years old. So to also look the best I ever have in my life is a massive bonus.
- Peptides
- Several, combined
- Duration
- —
- Goal
- Overall health
OOliverOver 50 · Health markers and body compositionVerified
First-hand reportSelf-reported
Training with injuries felt like a ceiling I'd never break through. Just three months in, strength up 60%, body composition transformed, and injuries resolved. The results have blown away my expectation.
- Peptides
- Retatrutide, BPC-157, TB-500
- Duration
- 3 months
- Goal
- Injury recovery, fat loss
BBlakeTraining around long-term injuriesVerified
First-hand reportSelf-reported
My ex-coaches said gaining muscle and losing fat at the same time was impossible. It turned out to be more than possible. And to be ageing at only 0.6 years per year and have a metabolic age seven and a half years younger than myself — to say I'm chuffed is an understatement.
- Peptides
- Retatrutide, MOTS-c, NAD+
- Duration
- —
- Goal
- Lose fat, keep muscle
KKasF · Athlete, body recompositionVerified