NAD+

A coenzyme, not a peptide. Oral precursors reliably raise blood NAD+ in trials, but health benefits are small and inconsistent; IV NAD+ is barely studied.

Also known as: Nicotinamide adenine dinucleotide, NAD, NMN and NR (oral precursors)
Area: Longevity
Status: Not an approved medicine for ageing; NR and NMN sold as supplements where permitted

Articles on NAD+

LongevityHuman RCT

Nicotinamide riboside raised NAD+ by about 60% in older adults. Nothing else clearly changed

In a six-week crossover trial of 24 healthy people aged 55 to 79, NR lifted NAD+ in blood cells and was well tolerated. Blood pressure hints were exploratory.

HPR Editorial · 21 Sept 2026 · 7 min read

LongevityHuman RCT

NAD+, NMN and NR: what the human trials actually show

Oral NR and NMN reliably raise NAD+ in blood, and one 10-week trial moved muscle insulin sensitivity by 25%. Beyond that the health effects are modest and mixed, and the injected form is the least studied route of all.

HPR Editorial · 13 Aug 2026 · 10 min read