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HPRHuman Peptide Research

MOTS-c

A 16-amino-acid peptide encoded in mitochondrial DNA; it improved metabolism and fitness in mice, but no human dosing trial has been published.

Also known as
mitochondrial open reading frame of the 12S rRNA-c, mitochondrial-derived peptide
Area
Metabolic
Status
Not an approved medicine in the UK or US; banned in sport (WADA S4.4)

Articles on MOTS-c

MetabolicPreclinical

MOTS-c: a real discovery, but no human trial yet

The body makes MOTS-c and exercise raises it; injected into mice it improved insulin sensitivity and fitness. No study has yet given it to people and published the results.

HPR Editorial · 13 Sept 2026 · 7 min read